VASCULAR BIOLOGY Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinases
نویسندگان
چکیده
1Institute for Molecular Cardiovascular Research, 2Institute for Pharmacology and Toxicology, and 3Interdisciplinary Center for Clinical Research Biomat, Medical Faculty, RWTH Aachen University, Aachen, Germany; 4Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden; 5Institute for Biochemistry, Christian-Albrechts-University, Kiel, Germany; and 6Cardiovascular Research Institute Maastricht, University Maastricht, Maastricht, The Netherlands
منابع مشابه
Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinases.
Junctional adhesion molecule A (JAM-A) is a transmembrane adhesive glycoprotein that participates in the organization of endothelial tight junctions and contributes to leukocyte transendothelial migration. We demonstrate here that cultured endothelial cells not only express a cellular 43-kDa variant of JAM-A but also release considerable amounts of a 33-kDa soluble JAM-A variant. This release i...
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